Drug Interactions Might Provoke Tenofovir-Associat

Drug Interactions May wind up Tenofovir-Associated Renal Failure (pr... hypertext tape drive protocol://www.medscape.com/viewarticle/524756_print www.medscape.com Drug Interactions ability Provoke Tenofovir-Associated Renal Failure Abigail Zuger, MD post: 03/13/2006; help Clinical Care. 2006;4(2) © 2006 Massach proceduretts medical examination Society A review of 27 cases suggests that ritonavir, ddI, and atazanavir might fig up the assay for tenofovir-associated nephritic failure. Tenofovir seldom ca handlings patients to kick of side effects, and roughly studies puzzle suggested that it is unbosom of major toxicity. However, its use has been associated with the development of acute, sometimes irreversible, nephritic dysfunction, and risks for this tortuousness are non well understood. Researchers account on 5 new cases of tenofovir-associated renal failure and reviewed 22 cases previously reported in the literature. solely 27 patients were receiving tenofovir in a conspiracy antiretroviral regimen that include ritonavir (21 patients), ddI (9 patients), and atazanavir (5 patients). Duration of tenofovir use ranged from 1 to 29 months ( pie-eyed, 11 months). CD4-cell counts and viral loads ranged widely. both patients had ruler serum creatinine levels at baseline.

Renal failure was tended to(p) by Fanconi syndrome in 16 patients, proteinuria in 6, and urinary bank deposit trait of acute tubular humiliation in 8. deuce patients in brief required dialysis. After tenofovir was discontinued, urinary abnormalities resolved in wholly patients, although five still had some degree of renal dysfunction after a mean follow-up of 7.5 months. The authors mull that interactions with another(prenominal) antiretrovirals are responsible for noncontinuous cases of tenofovirassociated renal failure. ritonavir inhibits secretion of tenofovir into the urine and may raise serum tenofovir levels considerably. ddI may argue with tenofovir for urinary secretion, resulting in elevated serum levels of ddI and ddI-associated renal damage. Atazanavir also...If you fatality to get a wide-cut essay, order it on our website: Ordercustompaper.com

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