Benzocaine Synthesis

Introduction: Naturally occu work party local anaesthetics suck been used for all over a century to plodding or alleviate the wound involved with medical procedures. Specifically, the cite of coca leaves was the first to be used. Its active ingredient, cocaine, was an effective anesthetic, merely its addictive t demiseencies caused it to be decrepit as an anesthetic and outlawed as a drug. With their greater effectiveness and fall side effects, synthetic anesthetics have fol low into common use. innate to the effectiveness of many of these anesthetics is the aromatic ring at uncomparable end and possibly a standby or 3rd amine at the other end of the molecule, seperated by a one- to four-unit hydrocarbon chain. In this experiment, we will synthesize benzocaine, one of the simpler local anesthetics, from para-amino benzoic acid and ethanol in the bearing of conc. sulfuric acid. ethyl aminobenzoate is an odorless, white, rhombohedric crystal with low water solubility. It is peeled to light flick and to temperatures above 30° C. As a drug, it has a low potency and low systemic toxicity. It is as well as a possible sulfonamide antagonist. Experimental: 1.20 g of p-amino benzoic acid and 12.0 mL of ethanol were added to a round-bottom flask with a magnetic stirbar. The classification was left to stir until the watertight dissolved.

1.0 mL of conc. sulfuric acid was slowly added and the commixture was allowed to genly cranch under reflux for about 75 minutes. After reaction, the mixture was allowed to cool and was transferred to a beaker conta ining 30 mL of water. 10% sodium carbonate! solution was added until gas was no longer evolved and the pH was around 8. The benzocaine was collected using vacuum filtration and was rinsed with water. The egress was allowed to air dry overnight. An infared spectrum in NUJOL was obtained, and the NMR spectrum in CDCl3 was run. represent MW mass (g) vol (mL) d (g/mL) m. p. (° C) mol p-amino benzoic acid 137.14 1.2 - 1.374 188 -189...If you requirement to abbreviate a full essay, order it on our website: OrderCustomPaper.com

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